Cutting is one of the oldest cultural practices. It is a fundamental way for human beings to enter into correspondence with materials. With these specific gestures and tools, people alter and reshape material boundaries and intertwine different entities. Those activities span across wide forms of tacit knowledge, from ancient craftsmanship to current high-tech procedures. In the domain of art, the cutting of text, music or film material produces new compositions that can provoke new insights. Similarly, in the domain of medicine, surgeons cut the body to understand and to heal it. Embedded in the way we think, write and speak, the act of cutting is ubiquitous: it means distinguishing and choosing between ›good‹ and ›bad‹ in a multitude of symbolic ways. A key component in cultural techniques, cutting is located at the interface between analog and digital technologies. Selecting this operation as a starting point opens up new perspectives, interactions and functions, whose limits and possibilities must be understood both practically and theoretically.
To this end, researchers in this project, from Anthropology, Biology, Computer Science, Design, Media Studies, Medicine and Physics jointly explore the entanglement of humans, materials and information. In diverse experimental settings, we explore the epistemological trade-off between precision and uncertainty in the preparation and execution of the cut on different scales and in new modes. In the following three primary settings and accompanying subprojects, we explore these new perspectives with the goal of contributing to a new repertoire of tools and practices that are renegotiating the divide between analog and digital.
Adaptive Digital Twin
The Adaptive Digital Twin project focuses on neuroscientific questions and predictive models concerning patients with brain tumors from different disciplinary perspectives. Subject-specific adaptive digital twin models are concepts that allow us to evaluate and simulate the effects of pathologies or tumor resectioning on the anatomy, function and connectivity of the central nervous system. In several subprojects, we explore new solutions for these specific questions in order to investigate practices of modeling, visualization, simulation and design. Interdisciplinary perspectives raise fundamental questions about the limits and possibilities of these methods beyond their concrete application, for example from an ethical, philosophical or sociological perspective.
Precon: Pre-conditioning of the human motor system by non-invasive transcranial magnetic stimulation (to reduce risk in neurosurgery). Copyright: Lucius Fekonja
Sensing Knife
The experimental setting Sensing Knife addresses specifically the sensing in the cutting and the cutting in the sensing. We evaluate the possibilities of creating an instrument that feels and acts “like the hand of a surgeon”, yet at a microscopic scale. The working case is the adaptation of the scanning force microscope, a technology currently used as a nanoscopic probing tool by physicists, into a knife for neurosurgery.
Scanning electron microscope image of the scanning probe microscope Silicon nitride sharp probe. At 99300x magnification. An apex radius of just 7 nm is typical. Copyright: Mohammad Fardin Gholami and Johannes Müller
Virtual Dissection
The Virtual Dissection setting aims to conceive a prototypical toolbox for experiencing anatomical information in virtual environments through its parameters of spatiality and resistance. The datasets to be employed are drawn from evolutionary biology and medicine. This approach is inspired by contemporary 3D scientific illustration practices and by the haptic dimension of knowledge in the historical practices of dissection.
- Brain Roads Event 24.10.2019–26.10.2019
- TMS Language Mapping Analysis Revisited News 13.2.2020
Fekonja, L. S. 2020. Anleitung zur klinischen Sprachtraktografie. https://doi.org/10.17169/refubium-26958
Tuncer, M., Salvati, L., Grittner, U., Hardt, J., Schilling, R., Bährend, I., Silva, L., Fekonja, L., Faust, K., Vajkoczy, P., Rosenstock, T., Picht, T. 2021. »Towards a tractography-based risk stratification model for language area associated gliomas.« NeuroImage: Clinical, 29, 102541. https://doi.org/10.1016/j.nicl.2020.102541
Wang, Z., Dreyer, F., Pulvermüller, F., Ntemou, E., Vajkoczy, P., Fekonja, L., Picht, T. 2021. »Support vector machine based aphasia classification of transcranial magnetic stimulation language mapping in brain tumor patients.« NeuroImage: Clinical, 29, 102536. https://doi.org/10.1016/j.nicl.2020.102536
Faghani, A., Gholami, M. F., Trunk, M., Müller, J., Pachfule, P., Vogl, S., Donskyi, I., Li, M., Nickl, P., Shao, J., Huang, M. R. S., Unger, W. E. S., Arenal, R., Koch, C. T., Paulus, B., Rabe, J. P., Thomas, A., Haag, R., Adeli, M. 2020. »Metal-Assisted and Solvent-Mediated Synthesis of Two-Dimensional Triazine Structures on Gram Scale.« Journal of the American Chemical Society, 142, (30): 12976-12986. https://doi.org/10.1021/jacs.0c02399
Fekonja, L., Wang, Z., Vajkoczy, P., Picht, T., Dreyer, F. 2020. »FV19 Lesion-symptom mapping of left perisylvian tumor patients with aphasic disorders.« Clinical Neurophysiology, 131, (4): e232. https://doi.org/10.1016/j.clinph.2019.12.109
Grisoni, L., Tomasello, R., Pulvermüller, F. 2020. »Correlated Brain Indexes of Semantic Prediction and Prediction Error: Brain Localization and Category Specificity.« Cerebral Cortex, https://doi.org/https://doi.org/10.1093/cercor/bhaa308
Le Calvé, M. 2020. »Apprendre à regarder le cerveau en 3D.« Anthropologie & Santé. Revue internationale francophone d'anthropologie de la santé, (21): https://doi.org/10.4000/anthropologiesante.6598
Le Calvé, M. 2020. »Intersecting Cartographic Imperative. Map-Making Practices of a Medical Artist in the Wake of the Computational Brain.« Kunstlicht, 41, (2-3): 81. https://tijdschriftkunstlicht.nl/maxime-le-calve-intersecting-cartographic-imperative-map-making-practices-of-a-medical-artist-in-the-wake-of-the-computational-brain-kunstlicht-vol-41-no-2-3-2020/
Fekonja, L., Wang, Z., Bährend, I., Rosenstock, T., Rösler, J., Wallmeroth, L., Vajkoczy, P., Picht, T. 2019. »Manual for clinical language tractography.« Acta Neurochirurgica, 161, (6): 1125-1137. https://doi.org/10.1007/s00701-019-03899-0
Maurer, M. M., Sauer, I. M., Pratschke, J., Tullius, S. G. 2019. »First Healthy Baby After Deceased Donor Uterus Transplantation.« Birth to a New Era? Transplantation, 103, (4): 652-653. https://doi.org/10.1097/TP.0000000000002627
Nyakatura, J. A., Baumgarten, R., Baum, D., Stark, H., Youlatos, D. 2019. »Muscle internal structure revealed by contrast-enhanced μCT and fibre recognition: The hindlimb extensors of an arboreal and a fossorial squirrel.« Mammalian Biology, 99, 71-80. https://doi.org/10.1016/j.mambio.2019.10.007
Tomasello, R., Kim, C., Dreyer, F. R., Grisoni, L., Pulvermüller, F. 2019. »Neurophysiological evidence for rapid processing of verbal and gestural information in understanding communicative actions.« Scientific Reports, 9, (1): 16285. https://doi.org/10.1038/s41598-019-52158-w
Tomasello, R., Wennekers, T., Garagnani, M., Pulvermüller, F. 2019. »Visual cortex recruitment during language processing in blind individuals is explained by Hebbian learning.« Scientific Reports, 9, (1): 3579. https://doi.org/10.1038/s41598-019-39864-1
Wölfer, J., Amson, E., Arnold, P., Botton‐Divet, L., Fabre, A., Heteren, A. H., Nyakatura, J. A. 2019. »Femoral morphology of sciuromorph rodents in light of scaling and locomotor ecology.« Journal of Anatomy, 234, (6): 731-747. https://doi.org/10.1111/joa.12980
Fekonja, L. S., Wang, Z., Vajkoczy, P., Picht, T. 2019. »Along-tract statistical analysis to detect early corticospinal tract impairment in brain tumour patients. Along-tract statistische Analyse zurFrüherkennung von Beeinträchtigungen dercorticospinalen Faserbahnbei Gerhirntumorpatienten.« Meeting Abstract. Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. 12.05. - 15.05.2019, Würzburg. https://doi.org/10.3205/19DGNC496
Fekonja, L. S., Wang, Z., Vajkoczy, P., Picht, T. 2019. »Automated tract segmentation in language tumour patients. Automatisierte Faserbahnsegmentierung bei Sprachtumorpatienten.« Meeting Abstract. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie, 12.05. - 15.05.2019, Würzburg. https://doi.org/10.3205/19DGNC303
Wang, Z., Fekonja, L., Vajkoczy, P., Picht, T. 2019. »rnTMS language speech mapping analysis in MNI space reveals neuronal functional reorganisation rnTMS Sprachmapping-Analyse im MNI space zeigt neuronale funktionale Reorganisation.« Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. DocP161. Düsseldorf: German Medical Science GMS Publishing House; 2019, https://doi.org/10.3205/19DGNC498
Fekonja, L. S., Wang, Z., Aydogan, D. B., Roine, T., Engelhardt, M., Dreyer, F. R., Vajkoczy, P., Picht, T. 2020. Code used in article "CSD-based metric for along-tract statistical analysis in primary motor tumor patients". https://doi.org/10.5281/zenodo.3732348
Mewes, D., Tournier, J-D., Picht, T., Fekonja, L. S. 2020. Implementation of OpenIGTLink tool in MRtrix3's mrview. mrtrix3-v0.1. https://doi.org/10.5281/ZENODO.3755569
Wang, Z., Fekonja, L. S., Dreyer, F., Vajkoczy, P., Picht, T. 2020. SVM code for article: Analysis of transcranial magnetic stimulation for object naming with machine learning classification shows reorganisation patterns in tumor patients. http://doi.org/10.5281/zenodo.3727664
Rabe, J. Matters of Free Energy and a Tesseract . Talk at the Annual Conference of the Cluster »Matters of Activity« 2020, 11 November 2020. https://www.virtualspace.matters-of-activity.de/annualconference/?id=4
Fekonja, L. S., Wang, Z., Vajkoczy, P., Picht, T. Automated tract segmentation in language tumour patients. Automatisierte Faserbahnsegmentierung bei Sprachtumorpatienten. Poster presentation at 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. 14 May 2019.
Le Calvé, M., Cubasch, A. J., Heitger, A. Shelf Life. Ferment-Activity and Nurturing Materials. Workshop. ExC MOA. 10 December 2020. https://www.matters-of-activity.de/en/activities/2915/shelf-life-ferment-activity-and-nurturing-materials
Fratzl, P., Schäffner, W. et al. Behavioral Matter: Composer avec le vivant. Workshop. Centre Pompidou, Paris. In cooperation with Ensadlab (École nationale supérieure des Arts Décoratifs, Paris) and the Cluster of Excellence »Matters of Activity«. 23 March 2019. https://fonds-perspektive.de/fr/behavioralmatter/
Picht, T., Fekonja, L. (PIs) 2019. Brain Roads. Interdisciplinary French-German project with Simatic, M. with ESAD de Reims; Télécom SudParis - Institut polytechnique de Paris; Charité-Universitätsmedizin Berlin. https://entreformesetsignes.fr/la-recherche/programme-datavisualisation/brain-roads